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After widespread DNA breaks in glioblastoma cells, changes in 3D genome organization, gene expression and epigenetic marks remained detectable for at least two weeks.
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01A computer-vision system analysed live endoscopic video during pituitary surgery. In the first six-patient series it ran successfully in four cases, with no AI-attributable complications, but clinical benefit has not yet been established.
02Chemically modified suppressor tRNA helped cells read through premature stop codons and restore full-length CFTR in preclinical cystic fibrosis models without editing genomic DNA.
03In an analysis of more than 572,000 people with pancreatic cancer risk factors, GLP-1 users had fewer diagnoses of the disease. The association was substantial, but the observational design cannot establish a preventive effect.
04A new study suggests that after brief intestinal inflammation, the extracellular matrix can stay altered for more than a year and keep reshaping how stem cells repair the gut lining. That may help explain how short-term damage can turn into chronic disease.
05Certain TP53 mutations may help tumors hide from innate immunity. The study links mutant p53 to RBM28, reduced double-stranded RNA, weaker interferon signaling, and resistance to immune checkpoint blockade.
06Cells temporarily suppress many DNA-repair pathways during mitosis. A Cell study shows that DDIAS protects exposed single-stranded DNA and is particularly important for developing neural cells.
07Repeated mild mechanical injury left human astrocytes in a persistently altered state. Their lipid output changed, and medium from the injured cells impaired human neurons in an in-vitro model.
08An experimental mutant-KRAS vaccine was tested in 20 people at inherited high risk of pancreatic cancer. Ninety percent developed a specific T-cell response, with some vaccine-induced T-cell clones persisting for up to two years.
09In mouse models, alcohol changed the cellular origins and immune state of liver cancer arising with metabolic disease. Tumors followed different developmental routes and responded differently to PD-1 blockade.
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